This learning object is a literature discussion based on a paper published in Nature (Labinger, J. A.; Bercaw, J. E. Nature 2002, 417, 507-514; doi:10.1038/446391a) discussing the mechanisms of C-H activation by transition metal complexes. This is a topic that could be covered at the end of a section on organometallic chemistry that shows a “newer” application. The attached lecture notes start at organic chemistry, then asks a question and is followed by a brief description of the paper showing examples for different mechanisms. The last slide is a thought slide that can easily be removed that asks a question that builds both upon what was discussed in the lecture and previous organometallic lectures. A working knowledge of counting electrons is required before beginning this study.