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Description
This is a literature discussion based on the paper “Spectroscopic Elucidation of the Inhibitory Mechanism of Cys2His2 Zinc Finger Transcription Factors by Cobalt(III) Schiff Base Complexes” by Heffern et. al. In Chemistry: A European Journal http://dx.doi.org/doi:10.1002/chem.201301659
| Attachment | Size |
|---|---|
| Schiff base zinc finger inhibitors_reading guide | 25.12 KB |
Learning Goals
Students will be able to:
- read and comprehend the primary literature article
- name cobalt coordination complexes
- apply HSAB theory to cobalt(III)-Schiff base complexes and metal ion binding of zinc finger proteins
- apply the ligand spectrochemical series to determine the spin state of a cobalt(III)-Schiff base complex
- verbalize their answers to a series of questions and use these answers to develop answers to more detailed questions that arise during a discussion
- interpret and explain the results from various spectroscopies
Related activities
Time Required
1 class period
Evaluation
Evaluation Methods
Collection of Reading Guide, evaluation of discussion
Evaluation Results
This LO was developed at the 2014 IONiC/VIPEr workshop Bioinorganic Applications of Coordination Chemistry and has not yet been evaluated.
Creative Commons License
Attribution, Non-Commercial, Share Alike CC BY-NC-SA