This Five Slides About provides an overview of the concept of magnetic susceptibility for paramagnetic metal centers. Three methods are discussed, namely the Evans NMR Method, the magnetic balance and SQUID (Superconducting QUantum Interference Device). The availability of each method varies across institutions.
The following paper will be given to the students to study at home along with the questions in the attached document. Students will be allowed to discuss their answers in small groups and refine their answers, before the corresct answer is revealed.
The students will not need to see the actual spectra that are in the SI to be able to address the given questions, the spectra can be projected to the class when the answers of the student groups are discussed
Origins of Enantioselectivity during Allylic Substitution Reactions Catalyzed by Metallacyclic Iridium Complexes.
In this literature discussion, students read a paper about a cobalt metallopeptide that imitates the active site of the enzyme nitrile hydratase. Specifically, the model complex is oxidized by air to produce a coordination sphere with both cysteine thiolate and sulfinic acid ligands, much like the post-translationally oxidized cysteine ligands in the biological system.
This five slides about chemical exchange transfer (CEST) discusses the magnetic properties of paramagnetic metal ions and their use as MR imaging agents. This includes tranditional contrast agents that affect the relaxation rate of nearby water protons and paramagnetic shift reagents suitable for CEST imaging applications. A recent redox-active cobalt complex is presented as an innovative agent for mapping redox imbalances in vivo.
In this experiment, students will synthesize a cobalt Schiff base complex with varying axial ligands ([Co(acacen)L2]+). They will characterize the complex using various techniques, and may perform computational modeling to predict spectroscopic properties.
This is a literature discussion based on the paper “Spectroscopic Elucidation of the Inhibitory Mechanism of Cys2
Students are asked to read an article detailing the development of a cobalt-based MRI contrast agent ("A Redox-Activated MRI Contrast Agent that Switches Between Paramagnetic and Diamagnetic States", Tsitovich, P. B.; Spernyak, J. A.; Morrow, J. R. Angew. Chem. Int. Ed. 2013, 52, 14247-14250, DOI: 10.1002/anie.201306394). Before coming to class the students are asked to answer a series of questions designed to guide them through the first half of the article, and to be prepared to discuss their answers in class.
31-P NMR spectrum of alpha-dodecatungstophosphoric acid is a combination of thirteen spectra, each spectrum representing the compound with a different number of 183W isotopes per molecule. In order to fully interpret the spectrum one needs to apply binomial distribution to calculate the mole fractions of the molecules with various numbers of 183W isotopes.
This LO requires an understanding of the satellites concept in NMR spectroscopy, originating from coupling with nuclei whose NMR active isotopes are not 100% abundant.
This is the second part of a two-day class discussion on molecular and inorganic spectroscopy. In this activity, upper level students learn about spectroscopic tecniques used in inorganic chemistry and then devise an experiment to follow the progress of a hypothetical reaction. The activity also prepares students for the inorganic laboratory "Linkage isomerism of nitrogen dioxide" in which infrared spectroscopy is used to monitor changes to the N-O vibrational stretch upon coordination to a metal.
This learning object focuses on a recent publication (Acta Crystallographia 2014, C70, 260 -266) by the Collins research group in the Department of Chemistry at The College of Wooster. Specifically, the paper evaluates the coordination diversity of a N-donor ligand, 2-phenyl-1,10-phenanthroline(pnp) with three new pnp-metal complexes containing Au(III), Cu(II), and Pd(II) metal centers.