Submitted by Kyle Grice / DePaul University on Thu, 07/17/2014 - 15:07
Additional Authors
Clifford Rossiter / SUNY Potsdam
EGunn / Simmons College
Laurel Goj Habgood / Rollins College
Marion Cass / Carleton College
Sherzod / Northwestern University
My Notes
Categories
Prerequisites
Biology
General Chemistry
Corequisites
No Corequisites
Course Level
Second year
Upper Division/Graduate
Topics Covered
Chemical literature
Periodic trends
Thermodynamics
Subdiscipline
Bioinorganic Chemistry
Coordination Chemistry
Description

This is a literature discussion of a review by Tom O'Halloran (The link to the paper is included in the "Web Resources" below). The review covers concepts of metal content in cells, metal trasport, storage, and regulation. Its a good review to start a broader or deeper discussion about metals in biology. We have provided some questions to help guide the student discussion. These questions can be given to students prior to coming to class, and the answers can either be used for the in-class discussion and/or collected. 

Attachment Size
O'Halloran Literature Discussion Qs.docx 20.36 KB
Learning Goals
Students will:
-- apply fundamental concepts from class material to literature examples, such as metal binding specificity (dependent on size, charge, etc.), Kd, strength of ligand binding, concentration and turnover of free ions 
-- gain an appreciation for the importance of transition metals in biological systems and the different roles metals play in the cell (metalloenzymes, metallochaperones and metalloregulatory proteins)
-- develop scientific reading comprehension in a guided activity
Related activities
Metals in Biological Systems - Who? How? and Why?
The Iron that Keeps and Kills Us
Exploding the Myth of Intracellular free metal ion pools_ A reading guide
Bioinorganic Chemistry- Metals in Purely Structural Roles
Utilizing the PDB and HSAB theory to understand metal specificity in trafficking proteins
The "Zinc Spark" - Zinc as a signaling chemical in life
Implementation Notes

Access the manuscript through your library and provide a copy of the manuscript to the students along with the discussion questions a few days before class, and then have an in class discussion abou the chapter. 

Time Required
45 minutes (1 lecture) + student time prior to lecture
Web Resources
O'Halloran Paper Link
Evaluation
Evaluation Methods

This literature discussion developed at the 2014 IONIC VIPER workshop and has not been evaluated yet. 

Creative Commons License
Attribution, Non-Commercial, Share Alike CC BY-NC-SA